Borrell Lab
News
We are hiring!!
16 February 2024 - We are hiring post-docs for our ERC SyG UNFOLD to study the cellular and genetic bases of cerebral cortex folding. Check out our job offer.
Start date: 1 April 2024
Duration: 3 years
Website: https://unfold-lab.github.io/
ERC-SyG awarded to study brain folding
26 October 2023 - Our lab was just awarded an ERC Synergy Grant!!! With the UNFOLD project we are going to study the causes and consequences of cerebral cortex folding, from a perspective across the scientific fields of biology, physics and computational modeling. UNFOLD will be coordinated by our lab and developed together with the labs of Kristian Franze (FAU Erlangen, Germany), Laurent Nguyen (Univ. Liege, Belgium) and Roberto Toro (Pasteur Institute, France).
We are hiring postdocs!!! - see job offer link
Candidates, email vborrell@umh.es
Thesis defense by Lucia Del Valle Antón
20 October 2023 - Lucia Del Valle Antón defended today her PhD Thesis with great success!! Fantastic presentationa nd phenomenal defense in front of a challenging committee (Fiona Francis, Simon Hippenmeyer and Jose-Pascual López Atalaya). Congratulations Lucia, we are super proud of you!!!
News
Extraordinary Thesis Award to Ana Villalba
21 December 2022 - We are thrilled to announce that our former lab member Ana Villalba, now a post-doc at IST Austria, was just awarded the Extraordinary PhD Thesis Award by Universidad Miguel Hernández for her work in our lab. Very much deserved award to an extraordinarily talented and hard working young scientist.
Congratulations Ana!!!
News
Hot off the press September 2022!!
New study published in Proceedings of the National Academy of Sciences
6 September 2022 - We are happy for the publication of a collaborative study with the laboratory of Eduardo Soriano (University of Barcelona), demonstrating that Reelin originated from Cajal-Retzius cells and from GABAergic interneurons has partially overlapping but also distinct functions in the lamination of the cerebral cortex.
Vilchez-Acosta A, Manso Y, Cárdenas A, Elias-Tersa A, Martínez-Losa M, Pascual M, Álvarez-Dolado M, Nairn AC, Borrell V, Soriano E (2022) Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination. PNAS 119:e2120079119
Hot off the press June 2022!!
New review paper published in Developmental Neurobiology
24 June 2022 - The latest review paper from our lab was just published online in Developmental Neurobiology, a joint effort with Alex, Eduardo and Enrico, PhD students in the lab, where we discuss the current understanding of the genetic mechanisms that regulated cortical neurogenesis during evolution.
Espinós A, Fernández-Ortuño E, Negri E, Borrell V (2022) Evolution of genetic mechanisms regulating cortical neurogenesis. Developmental Neurobiology (doi:10.1002/dneu.22891)
News
Víctor promoted to CSIC Research Professor
8 April 2022 - Today we celebrate that our PI, Víctor Borrell, has been promoted to CSIC Research Professor, the highest rank as investigator within CSIC. Congratulations!!
News
Hot off the press February 2022!!
New study published in Cell Reports
15 February 2022 - We are proud to see published the main part of Ugo's PhD work, in collaboration between our lab and the labs of Alex Dayer and Denis Jabaudon, where we demonstrate th e cell type-specific role of two miRNAs, miR-137 and miR-22 in basal progenitor amplification and neuron migration, respectively, both key in cerebral cortex expansion during evolution.
Tomasello U, Klingler E, Niquille M, Mule N, Santinha AJ, de Vevey L, Prados J, Platt RJ, Borrell V, Jabaudon D, Dayer A (2022) MiR-137 and miR-122, two outer subventricular zone-enriched non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation. Cell Reports 38, 110381
News
Women in Science Day 2022
11 February 2022 - Today we celebrate #InternationalDayofWomenandGirlsinScience with our very own Virginia Fernández featured in the EMBO Press series of female lead and/or corresponding authors whose work was featured on the cover recently
News
Hot off the press January 2022!!
New study published in Science Advances
15 January 2022 - We are proud to see published the main part of Kaviya's PhD work in our lab, where we demonstrate the key role of MIR3607 in the evolutionary expansion of the mammalian cerebral cortex, and its secondary loss in the rodent lineage reducing cortex size and folding.
Chinnappa K, Villalba A, Márquez-Galera A, Prieto-Colomina A, Nomura Y, Cárdenas A, Llorens E, Soler R, Tomasello U, López-Atalaya JP, Borrell V (2022) Secondary loss of miR-3607 reduced cortical progenitor amplification during rodent evolution. Science Advances 8(2):eabj4010 Video
News
AECC Research Grant awarded to Borrell Lab
The Fundación Científica Asociación Española Contra el Cáncer has awarded one of its prestigious Research Grants to our lab to study ETMR (Embryonal Tumor with Multilayered Rosettes). ETMR is a rare type of pediatric tumor of embryonic onset, very poor prognosis, and extremely short survival after diagnosis, caused by defects in microRNA function. With this grant, our lab will investigate the cellular and genetic mechanisms underlying ETMR onset, and search for potential therapeutic strategies.