Papers

2023

Del-Valle-Anton L, Amin S, Cimino D, Neuhaus F, Dvoretskova E, Fernández V, Babal YK, Garcia-Frigola C, Prieto-Colomina A, Murcia-Ramón R, Nomura Y, Cárdenas A, Feng C, Moreno-Bravo, J.A, Götz, M, Mayer C and Borrell V (2024) Multiple parallel cell lineages in the developing mammalian cerebral cortex. Science Advances. 2024 10 (13), eadn9998

Singh A, Del-Valle-Anton L, de Juan Romero C, Zhang Z, Fernández Ortuño E, Mahesh A, Espinós A, Soler R, Cárdenas A, Fernández V, Lusby R, Tiwari V K and Borrell V (2024) Gene regulatory landscape of cerebral cortex folding. Science Advances 10(23), eadn1640

Fernández V, Borrell V (2023) Developmental mechanisms of gyrification. Curr Opin Neurobiol 80, 102711

Messé A, Hollensteiner KJ, Delettre C, Dell L-A, Pieper F, Nentwig LJ, Galindo-Leon EE, Larrat B, Mériaux S, Mangin JF, Reillo I, de Juan Romero C, Borrell V, Engler G, Toro R, Engel AK, Hilgetag CC (2023) Structural basis of envelope and phase intrinsic coupling modes of the cerebral cortex. NeuroImage, doi.org/10.1016/j.neuroimage.2023.120212

Abad-Perez P, Molina-Payá F.J., Martínez-Otero L, Borrell V, Redondo RL, Brotons-Mas JR (2023) Theta/Gamma co-modulation disruption after NMDAr blockade by MK801 is associated with spatial working memory deficits in mice. Neuroscience 519:162-176.

2022

Vilchez-Acosta A, Manso Y, Cárdenas A, Elias-Tersa A, Martínez-Losa M, Pascual M, Álvarez-Dolado M, Nairn AC, Borrell V, Soriano E (2022) Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination. PNAS 119:e2120079119 Video

Espinós A, Fernández-Ortuño E, Negri E, Borrell V (2022) Evolution of genetic mechanisms regulating cortical neurogenesis. Developmental Neurobiology 82(5):428-453

Tomasello U, Klingler E, Niquille M, Mule N, Santinha AJ, de Vevey L, Prados J, Platt RJ, Borrell V, Jabaudon D, Dayer A (2022) MiR-137 and miR-122, two outer subventricular zone-enriched non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation. Cell Reports 38, 110381

Chinnappa K, Villalba A, Márquez-Galera A, Prieto-Colomina A, Nomura Y, Cárdenas A, Llorens E, Soler R, Tomasello U, López-Atalaya JP, Borrell V (2022) Secondary loss of miR-3607 reduced cortical progenitor amplification during rodent evolution. Science Advances 8(2):eabj4010 Video

Del Valle Anton L, Borrell V (2022) Folding brains: from development to disease modeling. Physiological Reviews 102:511-550

2021

Borrell V (2021) Protomaped by the pros: proneural factors pattern cortex folding. Neuron 109:2797-2798

Prieto A, Fernández V, Chinnappa K, Borrell V (2021) MiRNAs in early brain development and pediatric cancer. Bioessays 2100073

Hirota Y, Ohtaka-Maruyama C, Borrell V (2021) Editorial: The Extracellular Environment in Controlling Neuronal Migration During Neocortical Development. Frontiers in Cell and Developmental Biology 9, 1045

Villalba A, Götz M, Borrell V (2021) The regulation of cortical neurogenesis. Current Topics in Developmental Biology 142:1-66 Cover

Tomasello U, Klingler E, Niquille M, Mule N, de Vevey L, Prados J, Santinha AJ, Platt RJ, Borrell V, Jabaudon D, Dayer A (2021) MiR-137 and miR-122, two outer subventricular zone-enriched non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation. bioRxiv

Cárdenas A, Borrell V (2021) A protocol for in ovo electroporation of chicken and snake embryos to study forebrain development. STAR Protocols, 2:100692

2020

Messé A, Hollensteiner KJ, Delettre C, Dell L-A, Pieper F, Nentwig LJ, Galindo-Leon EE, Larrat B, Mériaux S, Mangin JF, Reillo I, de Juan Romero C, Borrell V, Engler G, Toro R, Engel AK, Hilgetag CC (2020) Structural basis of envelope and phase intrinsic coupling modes of the cerebral cortex. bioRxiv, 500009

Amin S, Borrell V (2020) The Extracellular Matrix in the evolution of cortical development and folding. Frontiers in Cell and Developmental Biology 8, 1486

Borrell V (2020) Recent advances in understanding neocortical development. F1000Research

Fernández V, Martínez-Martínez MA, Prieto-Colomina A, Cárdenas A, Soler R, Dori M, Tomasello U, Nomura Y, López-Atalaya JP, Calegari C, Borrell V (2020) Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium. EMBO J 19:e105479 Cover Video

2019

Cárdenas A and Borrell V (2019) Molecular and cellular evolution of corticogenesis in amniotes. Cell Mol Life Sci 77(8):1435-1460

Llinares-Benadero C and Borrell V (2019) Deconstructing cortical folding: genetic, cellular and mechanical determinants. Nat Rev Neurosci 20:161-176 Cover Video

Delettre C, Messe A, Dell L-A, Foubet O, Heuer K, Larrat B, Meriaux S, Mangin J-F, Reillo I, de Juan Romero C, Borrell V, Toro R, Hilgetag CC (2019) Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain. Netw Neurosci 3:1038-1050

Murcia-Belmonte V, Coca Y, Vegar C, Negueruela S, de Juan C, Valiño A, da Silva R, Kania A, Martínez-Otero L, Borrell V, Erskine L and Herrera E (2019) A retino-retinal projection guided by Unc5c emerged in species with retinal waves. Curr Biol 29(7):1149-1160.e4

Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broic L, Kumar Sahu S, Hirst W, Schlichthärle T, De Juan Romero C, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Staininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Bräuninger M, Nguyen L, Götz M (2019) The centrosome protein Akna regulates neurogenesis via microtubule organization. Nature 567:113-117

Martínez-Martínez MA*, Ciceri G*, Espinós A*, Fernández V, Marín O†, Borrell V† (2019) Extensive branching of radially-migrating neurons in the mammalian cerebral cortex. J Comp Neurol 527(10):1558-1576 (*co-authors; †co-corresponding)

2018

Cárdenas A, Villalba A, De Juan Romero C, Picó E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V (2018) Evolution of cortical neurogenesis in amniotes controlled by Robo signaling levels. Cell 174:590-606.e21 F1000Prime

Borrell V (2018) How cells fold the cerebral cortex. J Neurosci 38:776-783

2017

Reillo I*, De Juan Romero C*, Cárdenas A, Clascá F, Martínez-Martínez MA, Borrell V (2017) A complex code of extrinsic influences on cortical progenitor cells of higher mammals. Cerebral Cortex 27:4586-4606 (*co-authors) Cover

Huntenburg J, Wagstyl K, Steele C, Funck T, Bethlehem R, Foubet O, Larrat B, Borrell V, Bazin PL (2017) Laminar Python: tools for cortical depth-resolved analysis of high-resolution brain imaging data in Python. Research Ideas and Outcomes 3:e12346

Del Toro D, Ruff T, Cederfjäll E, Villalba A, Seyit-Bremer G, Borrell V, Klein R (2017) Regulation of cerebral cortex folding by controlling neuronal migration via FLRT adhesion molecules. Cell 169:621-635 Cover, Developmental Cell previews (22/5/2017), F1000Prime

De Juan Romero C, Borrell V (2017) Genetic maps and patterns of cerebral cortex folding. Curr Opin Cell Biol 49:31-37

Florio M, Borrell V*, Huttner W* (2017) Human-specific genomic signatures of neocortical expansion. Curr Opin Neurobiol 42:33-44 (*co-corresponding)

2016

Martínez-Martínez M, De Juan Romero C, Fernández V, Cárdenas A, Götz M, Borrell V (2016) A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels. Nat Comm 7:11812 (doi.org/10.1038/ncomms11812)

Fernández V, Llinares-Benadero C, Borrell V (2016) Cerebral cortex expansion and folding: what have we learned? EMBO J 35:1021–1044

2015

Moreno M, Fernández V, Monllau JM, Borrell V, Lerin C, de la Iglesia N (2015) Transcriptional profiling of hypoxic neural stem cells identifies calcineurin-NFATc4 signaling as a major regulator of neural stem cell biology. Stem Cell Reports 5:157-165

De Juan Romero C, Bruder C, Martínez-Martínez M, Tomasello U, Sanz-Anquela JM, Borrell V (2015) Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly. EMBO J 34:1859-1874 Cover, EMBO J Have you seen?

De Juan Romero C, Borrell V (2015) Coevolution of Radial Glial Cells and the Cerebral Cortex. Glia 63:1303-1319

Martínez-Martínez MA, Borrell V (2015) Developmental mechanisms of cerebral cortex expansion and folding: evolving towards human uniqueness. Biochemist 37:16-19

2014

Kielar M, Tuy FPD, Lebrand C, Bizzotto S, De Juan C, Poirier K, Oegama R, Mancini G, Bahi-Buisson N, Olaso R, Le Moing AG, Boutourlinsky K, Boucher D, Carpentier W, Berquin P, Deleuze JF, Belvindrah R, Borrell V, Welker E, Chelly J, Croquelois A, Francis F (2014) Mutations in the microtubule-associated protein Eml1 lead to ectopic progenitors and heterotopia formation during cortical development in mouse and human. Nat Neuroscience 17:923-933 Neuron News and Views (25/6/2014)

Borrell V*, Calegari F* (2014) Mechanisms of brain evolution: regulation of neural progenitor cell diversity and cell cycle length. Neurosci Res 86C:14-24 (*co-corresponding)

Borrell V*, Götz M* (2014) Role of Radial Glia cells in cerebral cortex folding. Curr Opin Neurobiol 27:39–46 (*co-corresponding)

Martínez-Martínez MA‡, Pacheco J‡, Borrell V*, Canals S* (2014) Phenotyping the central nervous system of the embryonic mouse by Magnetic Resonance Microscopy. Neuroimage 97:95-106 (‡co-authors; *co-corresponding)

2013

Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M (2013) Amplification of progenitors in the mammalian telencephalon includes a novel radial glia cell type. Nat Communications 4:2125

Nonaka-Kinoshita M, Reillo I, Artegiani B, Martínez-Martínez MA, Nelson M, Borrell V*, Calegari F* (2013) Regulation of Cerebral Cortex Size and Folding by Expansion of Basal Progenitors. EMBO J 32:1817-1828 (*co-corresponding) EMBO J Have you seen?, Science Editor’s choice 31/5/2013, F1000Prime

Stahl R, Walcher T, De Juan C, Pilz GA, Capello S, Irmler M, Sanz-Anquela JM, Beckers J, Blum R, Borrell V, Götz M (2013) TRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell 153:535-549 Science Now

Villar-Cerviño V, Molano-Mazón M, Catchpole T, Valdeolmillos M, Henkemeyer M, Martínez L, Borrell V, Marín O (2013) Cellular tiling in the cerebral cortex through contact repulsion. Neuron 77:457-471

2012

Borrell V*, Cárdenas A, Garcia-Frigola C, Galcerán J, Flames N, Ciceri G, Pla R, Nóbrega S, Peregrín S, Ma L, Tessier-Lavigne M, Marín O* (2012) Slit/Robo signaling modulates the proliferation of central nervous system progenitors. Neuron 76:338-352 (*co-corresponding) Video Abstracts

Teixeira C, Kron M, Masachs N, Zhang H, Lagace D, Martínez A, Reillo I, Duan X, Bosch C, Pujadas L, Brunso L, Song H, Eisch A, Borrell V, Howell B, Parent J, Soriano E (2012) Cell-autonomous inactivation of the Reelin pathway impairs adult neurogenesis in the hippocampus. J Neurosci 32:12051-12065

Llorens-Martin M, Teixeira CM, Fuster-Matanzo A, Jurado-Arjona J, Borrell V, Soriano E, Avila J, Hernández F (2012) Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer disease. J Alz Dis 29:921-930

Kelava I, Reillo I*, Murayama A*, Kalinka AT, Stenzel D, Tomancak P, Matsuzaki F, Lebrand C, Sasaki E, Schwamborn J, Okano H, Huttner WB‡, Borrell V‡ (2012) Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus. Cerebral Cortex 22:469-481 (*co-authors; ‡co-corresponding) Cover

Reillo I, Borrell V (2012) Germinal zones in the developing cerebral cortex of ferret: ontogeny, cell cycle kinetics and diversity of progenitors. Cerebral Cortex 22:2039-2054 Cover

Borrell V, Reillo I (2012) Emerging roles of neural stem cells in cerebral cortex development and evolution. Dev Neurobiol 72:955–971

2011

Reillo I, De Juan C, García-Cabezas MÁ, Borrell V (2011) A role for Intermediate Radial Glia in the tangential expansion of the mammalian cerebral cortex. Cerebral Cortex 21:1674-1694 Cover, F1000Prime

Callaway EM, Borrell V (2011) Developmental sculpting of dendritic morphology of layer 4 neurons in visual cortex: influence of retinal input. J Neurosci 31:7456-7470

Encinas JL, García-Cabezas MÁ, Barkovich J, Fontecha CG, Peiró JL, Soto GM, Borrell V, Reillo I, López-Santamaría M, Tovar JA, Farmer DL (2011) Maldevelopment of the cerebral cortex in the surgically induced model of myelomeningocele: implications for fetal neurosurgery. J Pediatr Surg 46:713-722

2010

Borrell V (2010) In vivo gene delivery to the postnatal ferret cerebral cortex by DNA electroporation. J Neurosci Methods 186:186-195

2006

Borrell V, Marin O (2006) The meninges control the tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling. Nat Neurosci 9:1284-1293 F1000

Borrell V*, Kaspar BK, Gage FH, Callaway EM (2006) In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cerebral Cortex 16:1571-1583 (*corresponding)

2005

Borrell V*, Yoshimura Y, Callaway EM (2005) Targeted gene delivery to cortical interneurons by directional in utero electroporation. J Neurosci Methods 143:151-158 (*corresponding)

2002

Borrell V*, Callaway EM (2002) Reorganization of exuberant axonal arbors contributes to the development of laminar specificity in ferret visual cortex. J Neurosci 22:6682-6695 (*corresponding)